Case Files Microbiology by Eugene Toy

Case Files Microbiology by Eugene Toy

Author:Eugene Toy
Language: eng
Format: epub
Publisher: McGraw-Hill Education
Published: 2015-11-18T16:00:00+00:00


TREATMENT AND PREVENTION

Several antiviral drugs have been developed to treat HSV infections, including acyclovir, valacyclovir, and famciclovir. All of these drugs function as inhibitors of viral DNA synthesis and are capable of shortening the duration of clinical symptoms and suppressing viral reactivation.

Prevention of HSV infection relies on the avoidance of direct contact with the virus or viral lesions. Asymptomatic shedding of virus can occur in infected persons in saliva, urethral, and cervical sources, and because only about one-fourth of individuals infected with HSV know that they are infected, safe sex practices are highly recommended to avoid spread. The vast majority of HSV infections in newborns can be prevented by cesarean delivery of neonates in women experiencing primary HSV-2 infection or recurrent genital lesions. This practice has significantly decreased the rate of neonatal infection and mortality. In addition, experimental recombinant HSV-2 vaccines are currently being developed and tested. One prospective trial has shown efficacy in preventing genital herpes infections in HSV-1 and HSV-2 seronegative women.



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