ADHD in Adults: A Practical Guide to Evaluation and Management (Current Clinical Psychiatry) by Craig B. H. Surman

Author:Craig B. H. Surman
Language: eng
Format: mobi
ISBN: 9781627032476
Publisher: Humana Press
Published: 2012-11-27T22:00:00+00:00

entially on these aspects. For example serotonin depletion leads to decreased response

inhibition without impacting on delay aversion. Eltoprazine is a serotonin

1A/1B

receptor agonist that has been shown to have anti-aggressive effects in animal stud-

ies. It has also been demonstrated to impair response inhibition but improve delay

aversion in rats. Unlike dexamfetamine these effects did not seem to breakdown at

high doses and at behaviourally effective doses there were no obvious effects on

striatal dopamine. A phase IIa trial has been completed and results reported in adults

with ADHD. The ADHD RS total score was reduced 42% compared to placebo and

the most common adverse effects were GI related (nausea, constipation, diarrhoea,

abdominal pain).

It is likely that other molecules are currently being trialed; however, given the

long lead time taken to get a new drug to market these are not likely to be clinically

relevant for many years. In the meantime as clinicians we need to continue to gather

evidence on current treatments and concentrate on providing high quality well

organised clinical care to ensure that we get the best out of the treatments currently

available to us and that our patients receive individually tailored treatments that, as

far as possible, optimise their outcomes.

References

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