Women’s Health in Autoimmune Diseases by Unknown
Author:Unknown
Language: eng
Format: epub
ISBN: 9789811501142
Publisher: Springer Singapore
12.11 Acute Fatty Liver of Pregnancy
Acute fatty liver of pregnancy is a microvesicular fatty infiltration of hepatocytes that develop during the second half of pregnancy. It is a rare complication and resembles Reye’s syndrome in its presentation with vomiting, hypoglycemia, lactic acidosis, hyperammonemia, elevated hepatic transaminases, conjugated hyperbilirubinemia, and evidence of disseminated intravascular coagulation. Hypertension, proteinuria, and thrombocytopenia are present in some cases, raising concern for preeclampsia and/or the HELLP syndrome. However, the finding of hypoglycemia points strongly to acute fatty liver as the correct diagnosis.
Treatment of acute fatty liver of pregnancy consists of fluids, glucose administration, correction of coagulopathy and immediate delivery. The value of plasma exchange is doubtful [7].
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