Thiamine Deficiency and Associated Clinical Disorders by David W. McCandless
Author:David W. McCandless
Language: eng
Format: epub
Publisher: Humana Press, Totowa, NJ
David W. McCandlessContemporary Clinical NeuroscienceThiamine Deficiency and Associated Clinical Disorders110.1007/978-1-60761-311-4_7© Humana Press, a part of Springer Science+Business Media, LLC 2010
Leigh’s Disease
David W. McCandless1
(1)Department of Cell Biology & Anatomy, Rosalind Franklin University, 3333 Green Bay Road, 60064 North Chicago, IL, USA
David W. McCandless
Email: [email protected]
Abstract
The disease subacute necrotizing encephalomyelopathy (SNE) was first described in 1951 by Denis Leigh and therefore is also called Leigh’s disease (Leigh, 1951). This disorder, although afflicting mainly children, has many features similar to those of Wernicke’s disease. These neuropathological features were so striking as to have been noted in the first case description by Dr. Leigh. Many studies have evolved over the years describing various biochemical features of Leigh’s disease. Most recently, genetic and mitochondrial alterations in brain, blood, and tissue of SNE patients have been described. This chapter will examine results from these studies in a chronological order and try to reach some valid conclusions and note where information is lacking.
Download
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.
Automotive | Engineering |
Transportation |
Whiskies Galore by Ian Buxton(40329)
Introduction to Aircraft Design (Cambridge Aerospace Series) by John P. Fielding(32338)
Small Unmanned Fixed-wing Aircraft Design by Andrew J. Keane Andras Sobester James P. Scanlan & András Sóbester & James P. Scanlan(32141)
Craft Beer for the Homebrewer by Michael Agnew(17445)
Turbulence by E. J. Noyes(7037)
The Complete Stick Figure Physics Tutorials by Allen Sarah(6638)
Kaplan MCAT General Chemistry Review by Kaplan(6053)
The Thirst by Nesbo Jo(5785)
Bad Blood by John Carreyrou(5768)
Learning SQL by Alan Beaulieu(5411)
Weapons of Math Destruction by Cathy O'Neil(5036)
Man-made Catastrophes and Risk Information Concealment by Dmitry Chernov & Didier Sornette(4735)
iGen by Jean M. Twenge(4702)
Digital Minimalism by Cal Newport;(4540)
Life 3.0: Being Human in the Age of Artificial Intelligence by Tegmark Max(4507)
Audition by Ryu Murakami(4098)
1,001 ASVAB Practice Questions For Dummies by Powers Rod(4038)
Electronic Devices & Circuits by Jacob Millman & Christos C. Halkias(4027)
Pale Blue Dot by Carl Sagan(4001)