The (E, Z) Isomerization of C-methoxycarbonyl-N-aryl Chlorohydrazones by Giorgio Molteni Fausto Cargnoni Raffaella Soave & Alessandro Ponti

The (E, Z) Isomerization of C-methoxycarbonyl-N-aryl Chlorohydrazones by Giorgio Molteni Fausto Cargnoni Raffaella Soave & Alessandro Ponti

Author:Giorgio Molteni, Fausto Cargnoni, Raffaella Soave & Alessandro Ponti
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Tags: Since chlorohydrazones are planar molecules, it is in principle possible to distinguish between their E and Z stereoisomers. Chlorohydrazones are known to preferentially assume the Z configuration around the C=N double bond, and their (E, Z) isomerization is almost suppressed at room temperature. The lack, or rather the difficulty, of such an isomerization has been conveniently addressed by the in-depth theoretical study of seven C-methoxycarbonyl-N-aryl chlorohydrazones (aryl = phenyl, 4-chlorophenyl, 4-bromophenyl, 4-iodophenyl, 2-chlorophenyl, 2-bromophenyl, and 2-iodophenyl). DFT B97M-D4/cc-pVTZ calculations of these C-methoxycarbonyl-N-aryl chlorohydrazones, supported by the XRD determination of the molecular structure, provided a complete picture of the isomerization processes in the studied compounds. The analysis of the energetics, molecular geometry, and electronic structure (the latter in the framework of the Quantum Theory of Atoms In Molecules) showed that the Z isomers are thermodynamically favored because, within the low-energy planar isomers with extensive conjugation, the electrostatic interactions between the dipoles of the C–O, C–Cl, and N–H bonds overcome the stabilization induced by the N–H O bond present in the E isomers. We confirmed that the (E, Z) isomerization occurs by the umklapp mechanism, in which the –NHAr moiety rotates in the molecular plane towards a linear C=N–N configuration and then proceeds to the other isomer. The (E, Z) isomerization is very slow at room temperature because the umklapp interconversion has high barriers (110 kJ/mol) despite the extended electron delocalization present in the transition state., chlorohydrazones; (E, Z) isomerization; DFT calculation; B97M; QTAIM; X-ray diffraction


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