Synthesis and Applications of Nanomaterials and Nanocomposites by Imran Uddin & Irfan Ahmad

Author:Imran Uddin & Irfan Ahmad
Language: eng
Format: epub
ISBN: 9789819913503
Publisher: Springer Nature Singapore

3.6.2 Passive Diffusion

Lipophilic NPs cross the lipid membrane via passive diffusion. The charge on NPs highly influences the diffusion of NPs across the membrane; cholesterol-containing lipid bilayer facilitates a 3-fivefold increase in uptake of NPs.

Negatively charged extracellular plasma membrane proteins impart negative surface charge to epithelial cells. Electrostatic interaction between positively charged NPs and negatively charged plasma membrane promote the association of NPs with the cell and cellular uptake by endocytosis [15].

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