PET-CT and PET-MRI in Oncology by Patrick Peller Rathan Subramaniam & Ali Guermazi

Author:Patrick Peller, Rathan Subramaniam & Ali Guermazi
Language: eng
Format: epub
Publisher: Springer Berlin Heidelberg, Berlin, Heidelberg

6.3 The Use of PET/CT

Newer imaging techniques such as PET/CT are integral to better diagnose and create more effective treatment regimens for patients with multiple myeloma. FDG PET is a superior modality for detecting bone marrow involvement in patients with multiple myeloma (Fig. 7). Bredella et al. (2005) showed that sensitivity of FDG PET in detecting myelomatous involvement was 85 and specificity was 92%. PET/CT is also able to distinguish between intramedullary and extramedullary lesions. In a study conducted by Nanni et al. (2006) additional lesions in the skeleton were detected in 16 of 28 patients with newly diagnosed multiple myeloma when using FDG PET/CT compared to whole-body X-ray. Although MRI is also useful in cases of multiple myeloma, Fonti et al. (2008) showed that FDG PET/CT performed better than MRI in the detection of focal lesions in whole-body analysis.

Fig. 7Staging: Multiple myeloma. This is a 65-year-old woman with multiple myeloma. The MIP PET (a) and axial PET/CT (b, c, d) images demonstrate diffuse FDG-hypermetabolic skeletal lesions in the axial and appendicular skeleton

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