Natural Bio-active Compounds by Mallappa Kumara Swamy & Mohd Sayeed Akhtar

Author:Mallappa Kumara Swamy & Mohd Sayeed Akhtar
Language: eng
Format: epub
ISBN: 9789811372056
Publisher: Springer Singapore

10.5.4 Plant Tissue Culture and Industrial Production of Metabolites

Reviewing the history of plant tissue culture application for production of metabolites, we come across examples for plant tissue culture-based in vitro processes which have been successful in the industrial production of metabolites for the cosmetic industry (Chermahini et al. 2011). The production of shikonin from Lithospermum erythrorhizon (Fujita and Tabata, 1986) by Mitsui Petrochemical Industries, Japan, is one of the earliest success stories. Following this many more cosmetic companies ventured into the in vitro methods for the production of metabolites for cosmetic preparation. Production of arbutin – a skin whitening agent – from Catharanthus roseus is yet another in vitro based commercial production of metabolite by Mitsui Petrochemical Industries, Japan (Yokoyama and Yanaigi 1991; Misawa1994; Chermahini et al. 2011). Likewise, a cosmetic company from Japan, Kibun, has formulated in vitro plant tissue culture technique for mass production of the cosmetic pigment carthamin from Carthamus tinctorius (Yamamoto et al. 2002; Haghbeen 2006). The commercial companies utilizing plant cell culture and hairy root culture technologies for the biosynthesis of natural products for effective and safe cosmeceuticals are on the rise (Table 10.2). The number of patents related to natural segment for the food, pharmaceutical, and cosmetic products by such technologies has crossed the 25,000 mark and is still rapidly escalating. There are a multitude of cosmeceutical products launched by companies which points to the commercial feasibility of using plant metabolites from in vitro grown cells. Grape cell-derived liposomes formed one of the key ingredients in the beauty cream, “PhytoCellTec” launched by Mibelle Biochemistry (Switzerland), which also acts as strong UV protector capable of delaying photoaging. “Stem cell acne cream” marketed by Emerge Labs, New York, is augmented with the multifaceted natural product – verbascoside extracted from cell cultures of lilac, Syringa vulgaris (SpecialChem 2012). This antiaging cream claims to reduce acne by 40% within a month of use and substantially reduces redness and inflammation of the skin. “ResistemTM” is yet another cosmeceutical product developed by a French company, Sederma, containing anthocyanin pigments of grape cell suspension cultures (Ananga et al. 2013).Table 10.2Plant tissue culture-derived natural products used in cosmeceutical industry

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