Microwave-Assisted Synthesis of Schiff Bases of Isoniazid and Evaluation of Their Anti-Proliferative and Antibacterial Activities by Bayan Ahed Al-Hiyari Ashok K. Shakya Rajashri R. Naik & Sanaa Bardaweel
Author:Bayan Ahed Al-Hiyari, Ashok K. Shakya, Rajashri R. Naik & Sanaa Bardaweel
Format: pdf
Tags: Three new Schiff bases of isoniazid were synthesized using microwave-assisted synthesis and conventional condensation with aromatic aldehydes. Synthesized compounds were characterized using elemental analysis, IR, NMR, and Mass spectroscopy. Synthesized compounds were evaluated for antiproliferative activity against MCF-7 cell line. The IC50 values were from 125 to 276 M. The compounds were also evaluated for antibacterial activity against Staphylococcus aureus and Escherichia coli. Results showed that the synthesized compounds produce significant antibacterial activity in vitro. Inhibition of compounds ranged from 13 to 18 mm., Schiff base; isoniazid; antiproliferative; antibacterial; microwave irradiation; MCF-7 cell lines; isonicotinic acid hydrazide; S. aureus; E. coli
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