Medically Important Plant Biomes: Source of Secondary Metabolites by Dilfuza Egamberdieva & Antonio Tiezzi

Author:Dilfuza Egamberdieva & Antonio Tiezzi
Language: eng
Format: epub
ISBN: 9789811395666
Publisher: Springer Singapore

8.7.2 Kakadumycins

Streptomycete sp. (NRRL30566) an endophyte of Grevillea pteridifolia is the source of peptide antibiotics kakadumycins. The structure of the antibiotic is related to a quinoxaline antibiotic, echinomycin. Like echinomycin, kakadumycins also have same mode of action. It can preferentially inhibit DNA-directed enzymatic RNA synthesis along with it and also can inhibit protein synthesis and cell wall synthesis to some extent. The antibiotic is reported to have strong antimalarial and anti-Bacillus anthracis activities (Castillo et al. 2003).

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