Mechanisms of Gene Regulation by Carsten Carlberg & Ferdinand Molnár

Author:Carsten Carlberg & Ferdinand Molnár
Language: eng
Format: epub
Publisher: Springer Netherlands, Dordrecht

6.6 Key Concepts

Nuclear receptors are transcription factors that are activated by small lipophilic ligands.

Nuclear receptors form the largest transcription factor family in metazoans (48 members in humans).

Nuclear receptor signaling is straightforward, since the activating signal, the ligand, passes cellular membranes and binds directly to the transcription factor, the nuclear receptor.

The members of the nuclear receptor superfamily are defined by a highly conserved DBD.

The nuclear receptor superfamily is subdivided into three classes: (i) endocrine receptors, (ii) sensors for dietary compounds and xenobiotics (adopted orphan receptors) and (iii) true orphan receptors.

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