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Introduction to Synthetic Biology by Mario Andrea Marchisio

Author:Mario Andrea Marchisio , Date: July 5, 2020 ,Views: 315

Introduction to Synthetic Biology by Mario Andrea Marchisio

Author:Mario Andrea Marchisio
Language: eng
Format: epub
ISBN: 9789811087523
Publisher: Springer Singapore


8.4 Protein-Protein and Chemical-Protein Interactions: A Model for the Toggle Switch

As described in Chap. 6, the Toggle Switch is made of two transcription units that repress each other. Moreover, each repressor can be inhibited by an input signal (i.e. a chemical or a thermal pulse). Equation (7.​3) presented a simplified model for the Toggle Switch where translation was treated as a single-step event and Hill functions were used to represent translation down-regulation. With BioNetGen we can derived a more detailed mechanistic model, fully based on mass action kinetics, that lies on the following assumptions each promoter contains two operators and each operator can be into two different states: free and taken by a repressor,



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Introduction to Synthetic Biology by Mario Andrea Marchisio.epub


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