IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity by Valérie Quesniaux Bernhard Ryffel & Franco Padova

Author:Valérie Quesniaux, Bernhard Ryffel & Franco Padova
Language: eng
Format: epub
Publisher: Springer Basel, Basel

6 Conclusions

Experimental autoimmune myocarditis is a helpful in vivo model to study the pathogenesis of human inflammatory heart diseases. It illustrates the cooperation between innate and adaptive immunity as the critical event triggering heart-specific autoimmunity and experiments with gene-targeted mice lacking specific cytokines and cytokine receptors greatly advanced our knowledge of the decisive pathogenetic pathways. It is not clear, however, to what extent these observations can be transferred to the human system. Additional studies are needed to identify self-pathogenic T cell subsets in patients with active myocarditis. Meanwhile, insights from the autoimmune myocarditis model nevertheless offer an attractive tool to develop innovative and novel treatment strategies.

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