DNA Helicases and DNA Motor Proteins by Maria Spies

Author:Maria Spies
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

Helicase–Primase as a Target for Herpes Antiviral Chemotherapy

The discovery and characterization of the HSV helicase–primase (HP) enzyme complex, covered in depth elsewhere in this volume, led to the quest for inhibitors of these functions that are essential for virus replication. Once inhibitors are identified they can be used to select for resistance mutations which can then inform the mechanistic studies. Furthermore, the discovery of potent inhibitors of an essential virus function leading to selective inhibition of virus replication can provide a path to successful antiviral chemotherapy. Several HP-inhibitors (HPI) with therapeutic potential have been discovered. The first of these resulted from rationale drug design programmes based on the screening of libraries of compounds in in vitro enzyme assays. However, ironically the current leading HPI undergoing clinical trials resulted from classical screening for inhibitors of virus replication that were serendipitously shown to be HPI.

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