Computer Modelling for Nutritionists by Mark Tomás Mc Auley
Author:Mark Tomás Mc Auley
Language: eng
Format: epub
ISBN: 9783319399942
Publisher: Springer International Publishing
It is known cholesterol biosynthesis is regulated homeostatically. This type of regulation employs negative feedback to counteract increased levels of hepatic free cholesterol . To model this, a function which captures the regulation of cholesterol synthesis by hepatic free cholesterol is needed. The equation I derived to represent this is similar to a Hill function and it is outlined in Eq. 4.1.
Where
(4.1)
HCSmax
Maximum rate of cholesterol synthesis
HFC
Hepatic free cholesterol
HCSt
Hepatic cholesterol synthesis threshold
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