Benign Breast Diseases by Catherine N. Chinyama
Author:Catherine N. Chinyama
Language: eng
Format: epub
Publisher: Springer Berlin Heidelberg, Berlin, Heidelberg
MGA exhibits a heterogenous immunocytochemistry staining pattern as demonstrated by Khalifeh et al. (2008). The cells are positive for S100 protein and epidermal growth factor (EGFR) but lack cytokeratin CK5/6 which stains the myoepithelial cells in benign lesions; but the cells are positive for CK8/18 which stain the luminal cells. MGA is negative for Her2 oestrogen and progesterone receptors. Epithelial membrane antigen (EMA) is also absent in MGA which differentiates this lesion from tubular carcinoma; the latter expresses EMA (Rosen 2009).
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