Basal Cell Carcinoma by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030268879
Publisher: Springer International Publishing

Interestingly, the incidence of NMSC increases in a linear fashion with the duration of immunosuppressive therapy. An Australian study reported an increase in skin cancer incidence from 7% at 1 year of immunosuppressive therapy to 82% at 20 years [17]. However, duration is not the only causative factor: the immunosuppressive regimen implemented also plays a significant role. For example, transplant patients who were placed on cyclosporine, azathioprine, and prednisolone were almost three times more likely to develop skin cancer when compared to patients on azathioprine and prednisolone alone [18]. Cyclosporine is a robust T-cell modulator. Transplant patients treated with cyclosporine have been shown to have significantly lower CD4 counts compared to age-matched controls [19]. Similarly, HIV patients have been shown to have a significantly increased risk of BCC and SCC [20]. The significance of CD4 lymphocytopenia is discussed further below. Table 8.1 summarizes the known risk factors for BCC.Table 8.1Risk factors for development of BCC

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