ABC Transporters and Cancer by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9780128013618
Publisher: Elsevier Science
Published: 2015-01-30T00:00:00+00:00

Figure 4 Amino acids in ABCB1, facing the lipid interface. The upper view (A) and side view (B) of the model of the ABCB1 protein created based on the structure of Sav1866 (Globisch, Pajeva, & Wiese, 2008). Lipid-facing amino acids identified by mutagenesis studies are indicated by stick representation in red color (for details see text). Figure is based on Loo et al. (2009).

Recently, relatively detailed atomic level crystal structures have become available for the homologues of human ABCB1, the Caenorhabditis elegans, and the mouse Abcb1 proteins (Aller et al., 2009; Jin, Oldham, Zhang, & Chen, 2012). Thus, proper localization of the amino acids within and outside the transmembrane helices can be estimated. Therefore, it can be expected that these structural data will greatly promote the assignment of additional lipid-sensing amino acid positions that can be further verified by site-directed mutagenesis studies.

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