Myelin by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9789813296367
Publisher: Springer Singapore

Keywords

Schmidt–Lanterman incisureSchwann cellMembrane skeletonProtein 4.1 familyMembrane palmitoylated protein familyCell adhesion moleculeCharcot–Marie–Tooth neuropathy

12.1 Schmidt–Lanterman incisure (SLI)

12.1.1 Structure of SLI

The Schmidt–Lanterman incisures (SLIs) are characteristic funnel-shaped structures in the internodes of myelinated nerve fibers in the PNS, formed in Schwann cell myelin, as demonstrated in the teased nerve fibers of the mouse sciatic nerves by the protein 4.1G immunostaining (Fig. 12.1a). Each SLI has three specific structural features, as schematically shown in Fig. 12.1b; (1) a coil spring shape due to its cytoplasmic continuity in the myelin roll, (2) the adhesion of membranes with adjacent membranes, and (3) swelling of the cytoplasm, which differs from the tight interactions of adjacent membranes in compact myelin (Terada et al. 2016). These three combinations indicate that SLIs work in a similar manner to a volute spring.

Fig. 12.1Structure of SLIs. (a) Light microscopically, SLIs are funnel shaped or truncated cone appearance in internodes (black arrowheads), demonstrated by the protein 4.1G immunostaining in the teased mouse sciatic nerve. Protein 4.1G is also localized in paranodes (black arrow). White arrowhead and arrow indicate Cajar bands. (b) Schematic model of SLI, which demonstrates three structural features: (1) swelling of cytoplasm, (2) adhesion of membranes, and (3) a coil spring. Some images were adapted from previous papers (Ohno et al. 2006; Terada et al. 2016), with permission

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