Interpenetrating Polymer Network: Biomedical Applications by Sougata Jana & Subrata Jana

Author:Sougata Jana & Subrata Jana
Language: eng
Format: epub
ISBN: 9789811502835
Publisher: Springer Singapore

6.8.4 Haematological Toxicity

Interaction of dendrimers with RBCs does not induce haemolysis only but also influences haematological parameters ascribed to polycationic nature of the unmodified dendrimers. The effect of dendrimers on different blood parameters including white blood corpuscles (WBCs), red blood corpuscles (RBCs), haemoglobin (Hb), haematocrit (HCT) and mean corpuscular haemoglobin (MCH) has been determined by various researchers using different analytical and chemical methods. Agashe et al. (2006) observed a significant decrease in RBC count, a substantial increase in WBC count, a decrease in Hb content and MCH value and a considerable difference in HCT value between control and PPI dendrimers using Erma particle counter method. RBC count, Hb, HCT and MCH values were found to decrease drastically to 4.43 ± 1.15, 8.26 ± 1.39, 27.06 ± 3.16 and 18.82 ± 1.06 from normal values of 7.15 ± 1.37, 14.89 ± 1.35, 41.69 ± 5.51 and 20.76 ± 1.35, respectively. Later Agrawal et al. (2007) also observed a significant increase in WBC count and decrease in RBC count, with 4.0 G PLL dendrimers. From these studies we may conclude that the cationic dendrimers have shown significant impairment in haematological parameters and this underlines the necessity to devise some strategy to render them more biocompatible.

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