Continuous Pharmaceutical Processing by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030415242
Publisher: Springer International Publishing

2.Better and more accurate predictive roll compaction models.

Promising recent work that utilized finite element simulations of the roll compaction process has shown that quantitative prediction of ribbon density distribution could be made when the streamwise stress at the roll inlet zone is known (Muliadi et al. 2013). However, there is currently no means for predicting and measuring that quantity. More importantly, finite element results have elucidated the reasons why the Johanson model, in its original form (1965), is inaccurate. The modifications to the Johanson models proposed by Bi et al. (2014) and Liu and Wassgren (2016) showed that reasonably accurate predictions for ribbon density are possible in the framework of a one-dimensional analytical solution, even if it must be combined with empirical calibrations or finite element modeling. The challenge, then, is to derive a fully analytical solution that addresses the shortcomings of the Johanson model, therefore allowing for accurate prediction of the ribbon density without the aid of at-scale empirical data and/or finite element results.

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