Viral Immunity by Williams J. E.;

Author:Williams, J. E.;
Language: eng
Format: epub
ISBN: 1788904
Publisher: Hampton Roads Publishing

Glutathione is mainly stored and metabolized in the liver, the organ most involved in detoxification processes. The liver is also one of the principle sites of common viral infections such as hepatitis B and C, as well as several of the Epstein-Barr viruses. Liver protection with natural medications and glutathione restoration becomes critically important in a viral immunity program.

Glutathione deficiency inhibits the natural immune response. It is thought to have potent antiviral activity, and low glutathione levels may cause a “pro-viral” effect. Adequate levels in the cells are necessary for T-cell proliferative response, activation of cytotoxic T cells, and other T-lymphocyte functions. Numerous studies have shown significant glutathione depletion in AIDS and HCV patients.

Effective glutathione restoration involves avoidance of substances that cause depletion, practicing detoxification regimens, and deliberate supplementation. Though low glutathione levels are associated with poor health and immune status, it is still unclear if oral supplementation is of any direct benefit to humans, even though some studies in mice indicate it has effectiveness in increasing natural killer cell activity.

Many of the antioxidants and amino acids discussed in this section increase glutathione levels, including vitamin C, NAC, and glutamine. Vitamin C supplementation (as little as 500 mg) in particular appears to significantly raise glutathione levels. Michael Murray, N.D., a naturopathic physician and a leading authority on natural medicine, strongly agrees and recommends that doctors avoid the use of the expensive glutathione supplements, suggesting that patients stay with vitamin C. The amino acid L-methionine and its activated form, S-adenosylmethionine (SAM), also raise glutathione levels.

Many toxic substances deplete glutathione including common over-the-counter drugs, especially acetaminophen (Tylenol). Meanwhile, NAC protects the liver against acetaminophen toxicity and is often recommended to be taken with acetaminophen in patients with compromised liver function. Other factors that cause glutathione deficiency include dietary methionine deficiency, ultraviolet exposure from sunlight, iron overload, tissue damage from injury or burns, and bacterial and viral infection. Patients with compromised immunity and chronic viral diseases should not take iron or iron-containing multivitamins; they should also avoid the use of acetaminophen and shun direct sun exposure.

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