Polyhydroxyalkanoates Biopolymers by Geeta Gahlawat

Author:Geeta Gahlawat
Language: eng
Format: epub
ISBN: 9783030338978
Publisher: Springer International Publishing

4.2 Engineering of Superior PHA Producing Strains

Recent advances in metagenomics and molecular biology helps in construction of superior PHAs producing strains to cater specific technological demands for reduction of production cost of PHAs. An industrial strain for PHA production should have the following characteristics: non-pathogenic, clear genomic background, fragile cell wall, easy genetic manipulation, easy flocculation, fast growing in a defined medium, no toxin production and possibly cellulose utilizing (Wang et al. 2014). With the above indispensable properties, it is not so difficult to incorporate other essential features for economical production e.g. high PHA accumulation capacity (80–90% of CDW), growth on mixed substrate, high substrate to polymer yield and production of SCL and/or MCL PHA. For efficient recovery of PHAs, the genetically modified strain should have a fragile cell wall, large cell size and easy or inducible flocculation (Kourmentza et al. 2017). Figure 4.1 shows desirable properties of an ideal strain for PHA industrial production. Thus, efforts of PHA commercialization mainly focuses on engineering strains that exhibit high PHA accumulation from renewable feed-stock, consume less energy for PHA synthesis, efficient and easy PHA recovery strategies, and tailored synthesis of functional PHA structures for high end applications.

Fig. 4.1Desirable properties for a PHA industrial production strain.

Reproduced from Wang et al. (2014) with permission from Elsevier

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