Magnetic Nanoheterostructures by Surender Kumar Sharma & Yasir Javed

Author:Surender Kumar Sharma & Yasir Javed
Language: eng
Format: epub
ISBN: 9783030399238
Publisher: Springer International Publishing

Magnetic Hyperthermia in Cancer Therapy

Although the growth of tumor can be ceased by warming cells up to 45 °C for 30 min (Fig. 7.8), it is challenging to raise the temperature of whole-body without causing hostile biochemical side effects (Yadavalli et al. 2016). At present, most of the studies have focused on the influence and level of efficiency of magnetic hyperthermia as a potential therapy for cancer treatment (Balivada et al. 2010; Jordan et al. 2006; Katafuchi et al. 1998). Yanase et al. (1998) in his initial work used magnetite with liposomes for the treatment of brain gliomas in mics and observed tumor size reduction from 30,376 to 2683 mm3 with three cycles of treatment. Interestingly, this specific case reveals utilization of magnetic hyperthermia in multi-site treatment, but metastatic tumor demands more systematic treatment. In 2006, Jordan et al. employed dextran-coated magnetic NPs for in vivo treatment of harmful glioblastomas with Fisher rats (Jordan et al. 2006). The researchers concluded like Yanase et al. (1998) also observed that there was substantial difference (p < 0.01) for the mean survival within monitoring and therapy groups statistically. When intra-tumoral temperature increased from 43 to 47 °C, the formation of precipitates also increased, indicating survival rate of the animal from 15.4 (±6.3) to 39.7 (±3.5) days, 4.5-fold further increase their survivability. In 2010, Balivada et al. (2010) separately utilized iron oxide and iron-based magnetic NPs for in vivo therapeutics of melanoma. It was revealed that statistically (p < 0.1) tumor weight decreased from 1.6 to 0.75 (control) mg as a result of magnetic NPs therapy. These studies confirmed that magnetic hyperthermia can decrease the viability of cancer cell lines and make it ineffective for whole tumor eradication.

Fig. 7.8Graph between rise in hyperthermia temperature with time at alternating field of 35mT at frequency of 250 kHz for cobalt ferrite powder synthesized by low temperature method (a), co-precipitation method (b) and hydrothermal method (c) (Yadavalli et al. 2016)

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