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Isolation and Antimalarial Activity of a New Flavonol from Tithonia diversifolia Leaf Extract by Talkmore Ngarivhume Anwar Noreljaleel Susanna L. Bonnet & Anke Wilhelm

Author:Talkmore Ngarivhume, Anwar Noreljaleel, Susanna L. Bonnet & Anke Wilhelm , Date: May 9, 2024 ,Views: 47

Isolation and Antimalarial Activity of a New Flavonol from Tithonia diversifolia Leaf Extract by Talkmore Ngarivhume Anwar Noreljaleel Susanna L. Bonnet & Anke Wilhelm

Author:Talkmore Ngarivhume, Anwar Noreljaleel, Susanna L. Bonnet & Anke Wilhelm
Format: pdf
Tags: An antiplasmodial activity-guided isolation was carried out on the dichloromethane extract of Tithonia diversifolia dried leaves. A total of five germacranolide type sesquiterpene lactones and a new flavonol, 3,6-dihydroxy-2-(4'-hydroxyphenyl)-7-methoxy-4H-chromen-4-one, were isolated. The flavonol reported an IC50 above 6.00 M against the chloroquine sensitive strain, NF54. The antimalarial activity of the Tithonia diversifolia dichloromethane leaf extract was attributed to orizabin and tagitinin C., Tithonia diversifolia; flavonols; antimalarial activity


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Isolation and Antimalarial Activity of a New Flavonol from Tithonia diversifolia Leaf Extract by Talkmore Ngarivhume Anwar Noreljaleel Susanna L. Bonnet & Anke Wilhelm.pdf


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