Hormonally Active Agents in the Environment by National Research Council

Author:National Research Council
Language: eng
Format: epub
Tags: Environment and Environmental Studies : Environmental Health and Safety. Health and Medicine : Environmental Health
Publisher: NATIONAL ACADEMY PRESS
Published: 1999-12-30T00:00:00+00:00

Species (Reference)

Dose

Resultsa and Limitations

Dog (Lehman 1965)

Males and females (22 total) fed 400-3,200 ppm (30.0-240.0 mg/kg/d) in diet for up to 4 yr.

No significant increased incidence of tumors in reproductive or other endocrine organs.

ENDOSULFAN

Rat Osborne-Mendel (NCI 1978b)

Males (50 per group) fed 408 ppm or 952 ppm (20.4 mg/kg/d or 47.6 mg/kg/d) in diet for 78 wk. Females (50 per group) fed 223 ppm or 445 ppm ( 11.1 mg/kg/d or 22.2 mg/kg/d) in diet for 78 wk.

No statistically significant increased incidence of tumors in reproductive or other endocrine organs in females.c The study is limited in that the dose was toxic to males. The high incidence of tumors in control animals (35% in mammary gland. 58% pituitary adenoma in females: 16% pituitary adenoma in males) raises concern about the interpretation of this study.

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