Cell and Molecular Biology (Lippincott's Illustrated Reviews Series) by Chandar Nalini;Viselli Susan

Author:Chandar, Nalini;Viselli, Susan [Chandar, Nalini;Viselli, Susan]
Language: eng
Format: mobi
Publisher: Lippincot (Wolters Kluwer Health)
Published: 2012-05-10T16:00:00+00:00

Figure 11.10

Transport into mitochondria.

Figure 11.11

Transport into peroxisomes.

Chapter Summary

• Proteins are synthesized either on free ribosomes or on ribosomes bound to endoplasmic reticulum.

• Ribosomes bind to endoplasmic reticulum when proteins they are synthesizing contain an N-terminal signal sequence or leader sequence.

• Ribosomes remain free when proteins they are synthesizing lack a leader sequence.

• The default pathway for proteins synthesized on bound ribosomes is to enter the lumen of the endoplasmic reticulum, then to move to the Golgi complex, and then to be secreted from the cell.

• Proteins destined to function in lysosomes receive a mannose-6-phosphate tag in the Golgi.

• Proteins secreted from the cell are released either in a constitutive or in a regulated manner.

• Proteins synthesized on free ribosomes will remain in the cytosol unless they contain a tag to direct them to the nucleus, mitochondria, or peroxisomes.

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