The Collectin Protein Family and Its Multiple Biological Activities by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030670481
Publisher: Springer International Publishing

Nippostrongylus brasiliensis

Nippostrongylus brasiliensis is a natural parasite of rat, closely related to human hookworm and is primarily used as an important model for studying host’s parasite immune response. Thawer et al showed that with N. brasiliensis infection, SP-D concentrations increased in the lung. rfhSP-D could bind to L4 parasites to enhance their killing by alveolar macrophages. N. Brasiliensis infection of SP-D−/− mice resulted in profound impairment of host innate immunity and ability to resolve infection (Thawer et al. 2016). With prior treatment of rfhSP-D, the number of IL-13 producing type 2 innate lymphoid cells (ILC2) was enhanced and increased production of the type 2 cytokines IL-4 and IL-13 (Thawer et al. 2016).

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