Precision Molecular Pathology of Breast Cancer by Ashraf Khan Ian O. Ellis Andrew M. Hanby Ediz F. Cosar Emad A. Rakha & Dina Kandil

Author:Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha & Dina Kandil
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

Basal-like Breast Carcinoma

Basal-like breast carcinomas (BLBC) is a distinct group of breast carcinoma that has evolved as a separate molecular subtype from gene expression profiling studies [23, 24]. They usually present as rapidly growing breast masses, most probably as “interval breast cancers” (those diagnosed between annual mammograms) [25]. Radiologically, they are often ill-defined, oval, round, or lobulated masses. Extensive necrosis may give the impression of a partially solid and cystic mass on ultrasound. Except for circumscription and geographic necrosis, BLBC shares a lot of histologic features with medullary carcinoma. The tumor is usually grade III invasive ductal carcinoma with focal/absent in situ component, high nuclear grade, absence of tubular formation, and high-mitotic rate. There is usually a dense stromal lymphocytic infiltrate, a solid architecture with pushing borders and areas of geographic necrosis (Fig. 11.3a). Like medullary carcinoma, BRCA-1 associated carcinomas are often BLBC.

Fig. 11.3Basal-like breast cancer. a H&E stain, 100×. b CK5/6 immunostain showing positive staining of the tumor cells. c IMP3 immunostain is diffusely positive

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