Microcirculation in Cardiovascular Diseases by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030478018
Publisher: Springer International Publishing

9.4 Large/Small Artery Cross-Talk in Hypertension

In essential hypertension, small and large artery alterations are closely interdependent. A temporal relationship is difficult to establish, and a cross-talk, by which small artery alterations influence larger artery phenotype and conversely large artery alterations influence small artery phenotype, described as a vicious circle is more likely than a linear sequence [1, 2].

9.4.1 Large/Small Artery Cross-Talk and Central Pulsatility

A cross-talk between small and large artery can be exemplified by the following vicious circle of small/large artery damages (Fig. 9.3), which can be described from any step. Each step refers to pathophysiological changes described above. When necessary, additional evidence is detailed. For instance, we can start the description from small artery damage:

Fig. 9.3Schematic representation of the large/small artery cross-talk: a vicious circle of aggravation between large and small artery alterations in essential hypertension

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