Liver Elastography by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030405427
Publisher: Springer International Publishing

LSM Predicts HCC Occurrence

The dose–response relationship between LSM and incident HCC was first described in the end of last decade. In a Japanese cohort of 866 patients with chronic hepatitis C (CHC), the hazard ratios (HRs) of incident HCC were 17, 21, 26, and 46 in patients with LS at 10.1–15.0 kPa, 15.1–20.0 kPa, 20.1–25.0 kPa, and >25.0 kPa, respectively (LS ≤10.0 kPa as reference) [3]. Subsequently, with slightly lower cutoffs for patients with chronic hepatitis B (CHB), the HRs of developing HCC were 3.1, 4.7, 5.6, and 6.6 in patients with LSM at 8.1–13.0 kPa, 13.1–18.0 kPa, 18.1–23.0 kPa, and >23.0 kPa, respectively (LSM ≤ 8.0 kPa as reference), in a Korean cohort of 1130 CHB patients (Fig. 34.1) [4]. In patients with CHB-related cirrhosis, patients of sub-cirrhotic range of LS (defined as <13.0 kPa) would have more than 50% lower risk of HCC development compared to those with cirrhotic range of LS [5].

Fig. 34.1The dose–response relationship between LS and incident hepatocellular carcinoma (HCC) in patients with chronic hepatitis B or C. Note that the risk of HCC is ca. 6x higher in CHB at LS values higher than 25 kPa as compared to CHC

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