Neglected Tropical Diseases - East Asia by Jürg Utzinger & Peiling Yap & Martin Bratschi & Peter Steinmann

Author:Jürg Utzinger & Peiling Yap & Martin Bratschi & Peter Steinmann
Language: eng
Format: epub
ISBN: 9783030120085
Publisher: Springer International Publishing

Genetics

Whole-genome analysis of several pathogenic treponemes has been performed, and several genetic differences between T. p. pallidum, T. p. pertenue, and T. p. endemicum have been identified. The regions of sequence divergence could be used for the molecular detection and discrimination of syphilis, yaws, and bejel strains, which are not possible with the currently available serological or molecular diagnostic tests.

The overall genetic sequence identity between T. p. pallidum and T. p. pertenue is 99.8% (Mikalová et al. 2010). In all strains, no major rearrangement is found and the gene order is nearly identical, further establishing the close genetic relationship. Analyses of sequences between nonhuman primate and human treponemal infections revealed a closer relationship between the Fribourg-Blanc simian treponemes and T. p. pertenue strains and showed that T. p. endemicum (Bosnia A strain) also clustered with T. p. pertenue strains, though more distantly than that of the Fribourg-Blanc isolate.

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