Introduction to Strategies for Organic Synthesis by Laurie S. Starkey

Author:Laurie S. Starkey
Language: eng
Format: epub
ISBN: 9781119347217
Published: 2018-05-01T00:00:00+00:00

Another possible approach is to view the target molecule as the product of a Wittig reaction with a stabilized Wittig reagent (or HWE reagent).

Retrosynthesis of TM via Wittig

This synthetic approach begins with the preparation of the Wittig reagent from methyl bromoacetate. Treatment of this reagent with benzaldehyde produces the target molecule.

Synthesis of TM via Wittig

Since the Wittig synthesis is a longer one that begins with a more complex starting material, the simpler aldol synthesis is likely to be the preferred route in this case.

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