Evaluating Evidence of Mechanisms in Medicine by unknow

Author:unknow
Language: eng
Format: epub, pdf
ISBN: 9783319946108
Publisher: Springer International Publishing

5.3 Search the Literature

A review question can then be used to search the literature for evidence for the contentious key features of a specific mechanism hypothesis. This should take place with the assistance of domain experts.

At this stage, decisions need to be made about which databases and other sources should be searched. These decisions should be documented in order to aid transparency and reproducibility. (See Appendix A for some examples of databases, Part II for tools to support the process of evidence appraisal, and Sect. 5.6 for a worked example of a literature search.)

One can identify research potentially relevant to the assessment of the specific mechanism hypothesis by looking at the relevant mechanistic study literature:1.In the first instance, this may be done by following up the references from the discussion section of any clinical study report which proposes a mechanism as the best explanation of an observed correlation. Any other publicly available reports may be useful here also, e.g., government agency reports, doctoral theses, etc.

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