Chemical Mixtures and Combined Chemical and Nonchemical Stressors by Cynthia V. Rider & Jane Ellen Simmons

Author:Cynthia V. Rider & Jane Ellen Simmons
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

9.7 Conclusions and Recommendations

This chapter has described the long history of using simple mathematical models to better understand the toxicity of mixtures. Over the course of the last 90 years, a lot of progress has been made in developing these tools. Despite the many overlapping approaches and the often confusing terminology, some basic principles have emerged.Simple mathematical models to predict mixture toxicity from individual chemical data provide a useful tool for exploring the joint action of chemicals. Most of the underlying toxicological concepts involve similarity or independence. In many cases, responses predicted using dose addition and/or independent action provide close approximations of observed mixture responses.

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