Antibody-Drug Conjugates by Kenneth J. Olivier Jr. Sara A. Hurvitz & Sara A. Hurvitz

Author:Kenneth J. Olivier, Jr.,Sara A. Hurvitz & Sara A. Hurvitz
Language: eng
Format: epub
ISBN: 9781119060802
Publisher: John Wiley & Sons, Inc.
Published: 2016-11-21T00:00:00+00:00

10.2 Pharmacokinetic Characteristics of an ADC

In contrast to small molecules or mAbs, the pharmacokinetics of ADCs are more complex due to the presence of multiple components and the interplay between those components. Table 10.1 shows the pharmacokinetic characteristics of ADCs compared to that of small molecules and mAbs. The overall pharmacokinetic characteristics (distribution, metabolism/catabolism, elimination) of ADCs are largely driven by its antibody component. However, characteristics of the other ADC components such as the linker and small molecule, as well as factors such as drug load and conjugation chemistry can also affect the pharmacokinetics and stability of an ADC.

Table 10.1 Comparison of ADC PK characteristics to small molecule and mAb.

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