Introduction to Drug Disposition and Pharmacokinetics by Curry Stephen H. Whelpton Robin. & ROBIN WHELPTON

Author:Curry, Stephen H.,Whelpton, Robin. & ROBIN WHELPTON
Language: eng
Format: epub
ISBN: 9781119261056
Publisher: John Wiley & Sons, Inc.
Published: 2017-01-24T00:00:00+00:00

8

Quantitative Pharmacological Relationships

Learning objectives

By the end of the chapter the reader should be able to:

draw annotated diagrams to demonstrate the relationship between drug concentration and effect

explain sigmoidicity and why it is important

explain how dose (concentration) and time combine to control the intensity and duration of drug effect

discuss direct response and indirect response models, including hysteresis

outline the principle of using effect compartments to integrate PK‐PD data.

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