Inoculated: How Science Lost its Soul in Autism by Kent Heckenlively

Author:Kent Heckenlively [Heckenlively, Kent]
Language: eng
Format: mobi
Publisher: Waterfront Press
Published: 2016-11-06T16:00:00+00:00

18 months

1.43

0.051

1.00 – 2.06

665

24 months

1.81

0.014

1.13 – 2.91

665

36 months

3.34

0.003

1.49 – 7.47

665

Table 3 – Case-control matched analysis for cohort excluding African American males

Age cut-off for first MMR vaccine

Hazard ratio (relative risk)

p-value

95% CI

Number of subjects

18 months

0.955

0.727

0.74 – 1.24

1666

24 months

0.986

0.937

0.70 – 1.39

1666

36 months

1.03

0.896

0.67 – 1.58

1666

As can be seen in Table 2, there exists a statistically significant relationship between the age of the first MMR vaccine and autism incidence at both the 24 month cut-off and the 36 month cut-off dates (p < 0.05). When applying corrections for type I errors (false positive), using the family-wise error rate, the p-value for African American males at 36 months still shows significance (adjusted p-value = 0.027). The result for the 18 month cut-off is marginally statistically significant with a p-value of 0.051 but this may be a false positive, considering we are doing multiple comparisons within the same dataset. Consistent with the results presented in my original paper, when African American males are removed for the cohort, there exists no statistically significant effect (Table 3). None of the other race/gender categories yielded statistically significant relationships (data not shown).

I also evaluated the original data using conditional logistic regression, following the matching reported by the CDC in their original Destefano et al. 2004 Pediatrics paper. Within this study, cases were matched to controls based on birthyear, gender and school attended. Results for this analysis are shown below.

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.