The Testosterone Optimization Therapy Bible: The Ultimate Guide to Living a Fully Optimized Life by Jay Campbell & Jim Brown

Author:Jay Campbell & Jim Brown [Campbell, Jay]
Language: eng
Format: azw3, epub
Publisher: Best Seller Publishing, LLC
Published: 2018-02-01T05:00:00+00:00

How does it Work?

After injecting Ipamorelin subcutaneously (i.e. under the skin), a selective pulse that lasts for roughly 3 hours stimulates the pituitary to release HGH. Once the HGH pulse is sent, it goes directly to the muscle to support development (i.e. lean muscle growth) while staying clear of any possible bone or cartilage growth. This is especially important as accidental growth in either of the two areas can lead to deformities later down the road.

For long-term Ipamorelin users, consistent usage will increase cell synthesis, elevate secretion levels of insulin from pancreatic tissue, and increase ghrelin in the stomach (which helps release HGH and control hunger). All of these functions work together to promote fat loss, improve the shuttling and absorption of nutrients, and potentially build skeletal muscle mass. This improves overall body composition and also minimizes, if not entirely suppresses unwanted side effects.

The pituitary gland releases HGH due to the action of chemicals that attach to two receptors: the Growth Hormone Releasing Hormone Receptor (GHRH-R) and the Growth Hormone Secretagogue Receptor (GHS-R).

The graph shows how combining a GHRH (Sermorelin, CJC-1295) with a GHS (Ipamorelin, GHRP-2, GHRP-6) causes synergistic release (i.e. their positive effects are combined to create one larger positive effect). GHS requires endogenous hypothalamic GHRH for maximal GH stimulation507.

Using Ipamorelin with a GHRH like Sermorelin or CJC-1295 without DAC, also known as DAC:GRF (short for drug affinity complex:growth hormone-releasing factor), will give users the biggest increase in GH and IGF-1. CJC-1295 without DAC is a 30-amino acid peptide hormone that will release a series of pulses over a long period of time.

GHRHs are paired specifically with GHRPs in order to create a synergy between the peptides that will unlock the body’s own stores of HGH, ultimately improving the benefits of Ipamorelin over time. Again, for a detailed discussion about why you would want to stack a GHRP with a GHRH, read Ben Greenfield’s excellent article, ‘How To Use Growth Hormone Stacks For A Better Body: Everything You Need To Know About IGF-LR3, GHRP, and GHRH Peptide Stacks’508.

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