Drugs, Poisons, and Chemistry, Revised Edition by Suzanne Bell Ph.D

Author:Suzanne Bell, Ph.D.
Language: eng
Format: epub
Tags: Science&Technology
ISBN: 9781438182605
Publisher: Chelsea House
Published: 2022-09-10T02:29:48+00:00

Pharmacokinetics and Toxicokinetics

Pharmacology is the study of how drugs (pharmaceuticals) are transformed in the body. Pharmacology can be roughly divided into two aspects: pharmacodynamics and pharmacokinetics. The term dynamics refers to movement or motion, while kinetics refers to speed or rate of movement. A simple distinction between the two terms is that pharmacodynamics focuses on the way a drug affects a person over time, while pharmacokinetics traces the route and rate of transformations of a drug once it is ingested.

Toxicologists are interested in pharmacokinetics because it provides a means of studying the concentrations of drugs and metabolites that may be found in blood and tissues as well as how a drug is metabolized and excreted over time. The term toxicokinetics is also sometimes used to describe the same phenomena when the substance ingested is toxic; it is considered a subdiscipline of pharmacokinetics. Elements of toxicokinetics include

modes of ingestion

rates of absorption and distribution

biotransformations and their rates

relative concentrations of drugs and metabolites in different tissues

rates of elimination

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