Characterizing the Properties of Anion-Binding Bis(cyclopeptides) with Solvent-Independent Energy Increments by Stefan Kubik

Author:Stefan Kubik
Format: pdf
Tags: The binding energies of 121 complexes between anions and bis(cyclopeptides) differing in the structure and the number of linking units between the two cyclopeptide rings were analyzed. These Gibbs free energies were obtained in earlier work for different anions, under different conditions, and with different methods. The multiparametric analysis of a subset of 42 binding energies afforded linear relationships that allowed the relatively reliable estimation of the iodide and sulfate affinity of three structurally related bis(cyclopeptides) in water/methanol and water/acetonitrile mixtures at different solvent compositions. Three parameters were required to achieve a satisfactory correlation, namely, the Gibbs free energy of transferring the respective anion from water into the solvent mixture in which complex stability was determined, and the Kamlet–Taft parameters and . Based on these relationships, the anion affinities of the other bis(cyclopeptides) were evaluated, giving rise to a set of energy increments that allow quantifying the effects of the linker structure or the nature of the anion on binding affinity relative to the reference system., anion recognition; anion receptors; statistical analysis; energy increments


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