The LDN Book by Linda Elsegood

Author:Linda Elsegood
Language: eng
Format: epub
Publisher: Chelsea Green Publishing
Published: 2016-02-16T17:50:49+00:00

Table 6.1. Outcome of Patients Treated with LDN with and without Antibiotics for RLS

Summary

More work remains to be done before we can recommend LDN to RLS patients. Various questions need to be addressed. With regard to the role in therapy, is LDN the drug best used for maintenance of SIBO treatment or can it be used for primary therapy? Concerns for pathophysiology are addressed by questions that include: Does it exert effect through improving SIBO via motility, does it change central or peripheral nerve pain via toll-like receptors and reduce neuroinflammation, and does it improve endorphin activity and hence improve dopamine nerve function in the setting of iron deficiency?

A double-blind, placebo-controlled study must be performed. Although this would ideally include patients with SIBO who have been treated with antibiotics first, it will be hard to determine the impact of the LDN since many patients seem to have immediate improvement with antibiotic treatment alone. It seems unlikely that antibiotic therapy could be implied to have a very long action alone. Alternatively, a double-blind study of LDN alone may show blunted results if the triggering factor is not treated first. Nonetheless, individuals appear to have had remarkable responses to LDN for long-term prevention of a disorder that rarely goes into spontaneous remission.

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