Structural Immunology by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9789811393679
Publisher: Springer Singapore

5.8 Summary

The important role of IL-17 cytokines in inflammatory and autoimmune diseases, especially IL-17A, has been firmly established through the remarkable efficacies in clinical trials of monoclonal antibodies against IL-17A. Non-antibody Il-17A antagonists have recently emerged as potential therapeutic alternatives. Further developments, though, are needed for these non-antibody compounds to advance to clinical trials. As described in this chapter, there has been significant progress in our understanding of the IL-17/IL-17R interaction through structures of both individual IL-17 cytokines and their complexes with both receptor and antagonists. These structures have already provided insight into the structural bases of IL-17 signaling and have suggested potential approaches in the development of selective, potent, non-antibody based IL-17A antagonists.

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