Stahl's Illustrated Antidepressants by Stephen M. Stahl

Author:Stephen M. Stahl
Language: eng
Format: mobi, azw3
ISBN: 9780521758529
Publisher: Cambridge University Press
Published: 2009-03-01T22:00:00+00:00

Thyroid as a Trimonoamine Modulator

FIGURE 6.3. Thyroid hormone binds to a nuclear hormone receptor that may lead to changes in neuronal gene expression that modulates one or more of the three monoamine neurotransmitters. Thus, thyroid hormone (T3, T4) can be considered a potential trimonoamine modulator (TMM). Patients who are theoretically deficient in one ore more of the three monoamines dopamine, norepinephrine or serotonin (top; see Figs. 1.9B and 6.2), despite treatment with an antidepressant, can have their monoamine activity theoretically restored when thyroid is added (bottom).

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