Mathematical Modelling of the Cell Cycle Stress Response by Elahe Radmaneshfar

Author:Elahe Radmaneshfar
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

(3.21)

where and are the rates of Sic1 binding to Cdc28-Clb5 and Cdc28-Clb2 to build C5 and C2 complexes, respectively.

We also assume that Sic1 binds to Cdc28P-Clb2 (PClb2), and use mass-action kinetics to model this reaction:

(3.22)

where captures the association rate of Sic1 to PClb2.

(iii) To enable the G1-to-S transition, Sic1 has to be inactivated. Cdc28 phosphorylates and consequently inactivates Sic1 [48]. We model the phosphorylation of Sic1 by Cdc28 using mass-action kinetics; the total concentration of Cdc28 is proportional to its concentration in complexes with cyclins:

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