Anxiety by Dr Mark Cross

Author:Dr Mark Cross
Language: eng
Format: epub
Publisher: ABC Books
Published: 2020-02-05T16:00:00+00:00

What they do

Antidepressants all work by adjusting levels and functioning of neurotransmitters – the chemicals that transmit signals between dendrites, which are the cells in your brain. A shortage of serotonin and noradrenaline are the main chemicals linked to anxiety and depression, and antidepressants work by increasing the availability of these chemicals by various means, including blocking the metabolism (breakdown) of the transmitters, making them more available, or by blocking their reabsorption at the receptor site in the brain.

SNRIs and mirtazapine: Increase the levels of the neurotransmitters serotonin and norepinephrine by inhibiting their reabsorption into brain cells.

SSRIs: Relieve anxiety symptoms by blocking the reuptake of serotonin by nerve cells in the brain, increasing the serotonin available, which improves mood. SSRIs are ‘selective’ because they affect only serotonin, not other neurotransmitters.

Tricyclics: Inhibit the reabsorption of the neurotransmitters serotonin and norepinephrine.

Agomelatine: Works by stimulating melatonin receptors (a hormone that has been shown to improve symptoms of anxiety by improving sleep quality, through regulating circadian rhythms) and improving motivation and sense of enjoyment.

Vortioxetine: Works by blocking reuptake of serotonin, as well as binding with certain serotonin receptors, increasing transmission and reducing symptoms.

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