A Comprehensive Guide to Nanoparticles in Medicine by Acharya Rituparna;

Author:Acharya, Rituparna;
Language: eng
Format: epub
Publisher: Bentham Science Publishers
Published: 2021-06-28T00:00:00+00:00

The drawbacks are as follows [79]:

Quantum dot nanoparticles have toxicity in the body when applied.

They degrade easily within the system.

They have a potential aggregation tendency.

Lastly, they are removed from the body easily.

CONCLUSION

The dynamic property of nanoparticles influences the association and dissociation curve of cells in the body fluid. Nanoparticles after establishment of contact with the biological environment cover the cells that are known as “halo”. The dynamic response of nanoparticles is determined by the concentration of protein in the biological fluid and construction of this “halo”. The unhealthy fluids bring remarkable changes in the dynamic nature of the nanoparticles. The mechanical properties of the unhealthy fluid produce a reasonable response in the nanoparticle [80].

siRNA-nanoparticle conjugates are considered to be the most potent therapeutic in the medicinal application. However, to make them optimum in their applications, more research in this field is required. Many challenges and barriers should be addressed before it becomes an optimum drug molecule in today’s world. Systemic delivery of siRNAs is the major challenge today. In this respect, nanoparticle-mediated delivery is emerging as a potent technology. A wide variety of nanoparticles has their advantages and drawbacks while administering in the human body due to their different physiochemical properties. They have a range of effectiveness when they are used in conjugation with siRNAs.

Silica nanoparticles may deliver large payloads due to their controllable porosity. Magnetic nanoparticles have unique properties that make them a theranostic agent. Carbon nanostructures due to their shape and size may penetrate the cell walls easily. As liposomes are made of lipid particles, they are highly biocompatible. Moreover, hydrogels have a highly porous structure that makes them an ideal controlled delivery and makes them carry high molecular weight payloads. Unit by unit construction of polymers makes them an efficient transfection and release nanoparticle.

These unique properties of the nanoparticles make them efficient in siRNA delivery to the cells and target organs. However, success will be achieved only after overcoming the barriers associated with other stages of delivery. Further, research is necessary to develop an optimum nanoparticle with unique properties that may deliver siRNA in an optimum way. The development of novel nanoparticles with ideal nanostructures can subsequently make the siRNA delivery a true potential for therapy.

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