The Vitamins by Gerald F. Combs Jr.; McClung James P.; & James P. McClung

Author:Gerald F. Combs, Jr.; McClung, James P.; & James P. McClung [Combs, Gerald F. & McClung, James P.]
Language: eng
Format: epub
Publisher: Elsevier Science
Published: 2016-12-16T19:18:51+00:00

• Passive diffusion—at higher concentrations (e.g., a 2.5 mg dose for a human).

Movement of thiamin across the enterocyte basolateral membrane into the blood is Na+-dependent, being coupled to the hydrolysis of ATP by a Na+/K+ ATPase. While most of the thiamin present in the intestinal mucosa is in phosphorylated form, thiamin arriving on the serosal side of the intestine is largely in the free (nonphosphorylated) monovalent cation. Therefore, the movement of thiamin through the mucosal cell is coupled to its phosphorylation/dephosphorylation.

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