Life's Greatest Secret by Matthew Cobb

Author:Matthew Cobb [Cobb, Matthew]
Language: eng
Format: epub
ISBN: 9780465062669
Publisher: Basic Books

That question remains unanswered.

In 2014, the ENCODE consortium published a second wave of papers and seemed to back away from their earlier headline claim of 80 per cent function, admitting that ‘it is not at all simple to establish what fraction of the biochemically annotated genome should be regarded as functional’. Instead, they emphasised their indisputable finding that an important part of the human genome seems to induce reliable biochemical activity of some kind:

The major contribution of ENCODE to date has been high-resolution, highly-reproducible maps of DNA segments with biochemical signatures associated with diverse molecular functions. We believe that this public resource is far more important than any interim estimate of the fraction of the human genome that is functional.105

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