Primer of Genetic Analysis by James N. Thompson Jr. Jenna J. Hellack Gerald Braver & David S. Durica & James N. Thompson Jr. & Jenna J. Hellack & Gerald Braver & David S. Durica

Author:James N. Thompson, Jr. Jenna J. Hellack Gerald Braver & David S. Durica & James N. Thompson, Jr. & Jenna J. Hellack & Gerald Braver & David S. Durica [Thompson Hellack Braver and Durica]
Language: eng
Format: epub
Publisher: Cambridge University Press
Published: 2013-04-11T16:00:00+00:00

III. Termination A. Three different codons can specify termination: UAA, UAG, and UGA.

B. When one of these appears in the A site, a termination protein causes the release of the polypeptide and breakdown of the ribosome complex.

C. The ribosomal units can then become part of another initiation complex.

The process of eukaryotic translation is similar to this but has the following important differences: Ribosomal subunits are 40S and 60S in size.

Methionine in the initiation complex is not formylated, but a special initiation tRNA is used.

Proteins involved in initiation, elongation, and termination differ from those in prokaryotes. The process establishing ribosome assembly at the appropriate initiation codon is also different.

In prokaryotes, translation of the mRNA molecule can occur while its transcription is still in progress. In eukaryotes, however, mRNA is made in the nucleus and must be moved to the cytoplasm to bind with ribosomes.